Subject(s)
Hemorrhagic Fevers, Viral , Rift Valley Fever , Arenaviruses, New World , Lassa Fever , Kyasanur Forest Disease , Marburg Virus Disease , Hemorrhagic Fever, American , Hemorrhagic Fever with Renal Syndrome , Severe Dengue , Hemorrhagic Fever, Omsk , Hemorrhagic Fever, Ebola , Hemorrhagic Fever Virus, Crimean-CongoABSTRACT
100 cases of Kyasanur Forest Disease were studied clinically and autopsy or postmortem biopsies of various organs were done in 8 cases. 1. Our study showed that KFD passes through 4 stages each lasting for about a week. i.e. a prodromal stage with fever, hypotension hepatomegaly, a stage of complication characterized by haemorrhage, neurological manifestation or bronchopneumonia, a stage of recovery followed by a li stage of fever in some cases. 2. The exact of cause of haemorrhage could not be identified though Disseminated Intravascular Coagulation was suspected. 3. Hypotension in KFD could be of Myocardial origin. 4. Encephalopathy in KFD could be due to a metabolic cause probably of hepatic origin. 5. Lung signs could be due to intraalveolar haemorrhage and secondary infection.
Subject(s)
Adolescent , Adult , Aged , Child , Child, Preschool , Disease Outbreaks , Female , Humans , India/epidemiology , Infant , Infant, Newborn , Kyasanur Forest Disease/epidemiology , Male , Middle Aged , Retrospective StudiesABSTRACT
Endogenous interferon (IFN) levels were monitored in acute (51) and convalescent phase (19) sera collected from patients suffering from Kyasanur forest disease (KFD). Levels of circulating IFN in the acute samples (GM 216.3 +/- 8.7) collected between 4 to 7 post onset day (POD) were significantly higher (P less than 0.001) than the convalescent samples (GM 13.19 +/- 1.6) collected between 30th to 90th POD. Interferonemia was concomitant with the viraemic phase. Neutralization studies indicated that the endogenous (circulating) IFN was antigenically similar to acid stable form of IFN-alpha.